circ_LRIG3 contributes to the progression of hepatocellular carcinoma by elevating RNF38 via sponging miR-449a

Circular RNAs (circRNAs) play crucial roles in multiple cancers, including hepatocellular carcinoma (HCC). However, the effects and molecular mechanisms of circ_LRIG3 HCC remain barely unknown. qRT-PCR assay was employed to detect levels circ_LRIG3, LRIG3, miR-449a ring finger protein 38 (RNF38). RNase R Actinomycin D were performed analyze characteristics circ_LRIG3. Colony formation MTT used evaluate cell proliferation. Flow cytometry analysis transwell adopted for apoptosis metastasis, respectively. Western blot carried out Ki67, Snail, E-cadherin, RNF38, Smad2/3 p-Smad2/3. Murine xenograft model explore role vivo. expression upregulated tissues cells. Knockdown suppressed proliferation, migration invasion facilitated cells vitro blocked tumor growth RNF38 overexpression reversed knockdown on malignant behaviors Moreover, could sponge positively modulate inhibited progression by sponging miR-449a. In addition, silencing might inhibit pathway. modulation miR-449a/LRIG3 axis, which provide a novel method therapy.